Article
Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies.
BMC genomics - 30 Aug 2007
Gonzalez-Neira Anna, Rosa-Rosa Juan Manuel, Osorio Ana, Gonzalez Emilio, Southey Melissa, Sinilnikova Olga, Lynch Henry, Oldenburg Rogier A, van Asperen Christi J, Hoogerbrugge Nicoline, Pita Guillermo, Devilee Peter, Goldgar David, Benitez Javier
Abstract excerpt
BACKGROUND: The recent development of new high-throughput technologies for SNP genotyping has opened the possibility of taking a genome-wide linkage approach to the search for new candidate genes involved in heredity diseases. The two major breast cancer susceptibility genes BRCA1 and BRCA2 are involved in 30% of hereditary breast cancer cases, but the discovery of additional breast cancer predisposition genes...
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