Article
A genome wide linkage search for breast cancer susceptibility genes.
Genes, chromosomes & cancer - 1 Jul 2006
Smith Paula, McGuffog Lesley, Easton Douglas F, Mann Graham J, Pupo Gulietta M, Newman Beth, Chenevix-Trench Georgia, Szabo Csilla, Southey Melissa, Renard Hélène, Odefrey Fabrice, Lynch Henry, Stoppa-Lyonnet Dominique, Couch Fergus, Hopper John L, Giles Graham G, McCredie Margaret R E, Buys Saundra, Andrulis Irene, Senie Ruby, Goldgar David E, Oldenburg Rogier, Kroeze-Jansema Karin, Kraan Jaennelle, Meijers-Heijboer Hanne, Klijn Jan G M, van Asperen Christi, van Leeuwen Inge, Vasen Hans F A, Cornelisse Cees J, Devilee Peter, Baskcomb Linda, Seal Sheila, Barfoot Rita, Mangion Jon, Hall Anita, Edkins Sarah, Rapley Elizabeth, Wooster Richard, Chang-Claude Jenny, Eccles Diana, Evans D Gareth, Futreal P Andrew, Nathanson Katherine L, Weber Barbara L, Rahman Nazneen, Stratton Michael R
Abstract excerpt
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome-wide linkage screens, which included a total of 149 multiple case breast cancer families. All families included at least three cases of breast cancer diagnosed below age 60 years, at least...
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