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Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage.

Human molecular genetics - 15 May 2009

Stanford Janet L, FitzGerald Liesel M, McDonnell Shannon K, Carlson Erin E, McIntosh Laura M, Deutsch Kerry, Hood Lee, Ostrander Elaine A, Schaid Daniel J

Abstract excerpt

The search for susceptibility loci in hereditary prostate cancer (HPC) has proven challenging due to genetic and disease heterogeneity. Multiple risk loci have been identified to date, however few loci have been replicated across independent linkage studies. In addition, most previous analyses have been hampered by the relatively poor information content provided by microsatellite scans. To overcome these issues,...

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Identifiers

PMID: 19251732
DOI: 10.1093/hmg/ddp100
PMCID: PMC2671990

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