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Whole-genome Linkage Analysis and Sequence Analysis of Candidate Loci in Familial Breast Cancer.

Anticancer research - 1 Jun 2015

Marikkannu Rajeshwari, Aravidis Christos, Rantala Johanna, Picelli Simone, Adamovic Tatjana, Keihas Markku, Liu Tao, Kontham Vinaykumar, Nilsson Daniel, Lindblom Annika

Abstract excerpt

BACKGROUND: Known breast cancer-predisposing genes account for fewer than 25% of all familial breast cancer cases and further studies are required to find the remaining high- and moderate-risk genes. We set-out to couple linkage analysis using microsatellite marker data and sequence analysis of linked regions in 13 non-BRCA1/2 families in order to find novel susceptibility loci and high-penetrant genes. MATERIALS...

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PMID: 26026075

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BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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