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Article

Localization of breast cancer susceptibility loci by genome-wide SNP linkage disequilibrium mapping.

Genetic epidemiology - 1 Jan 2006

Ellis Nathan A, Kirchhoff Tomas, Mitra Nandita, Ye Tian-Zhang, Chuai Shaokun, Huang Helen, Nafa Khedoudja, Norton Larry, Neuhausen Susan, Gordon Derek, Struewing Jeffery P, Narod Steven, Offit Kenneth

Abstract excerpt

We studied the feasibility of a novel approach to localize breast cancer susceptibility genes, using a low-density genome-wide panel of single-nucleotide polymorphisms and taking advantage of large regions of linkage disequilibrium (LD) flanking Jewish disease genes in high-risk cases. With Affymetrix GeneChip arrays, we genotyped 8,576 polymorphisms in three sets of Ashkenazi Jewish breast cancer cases: a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16206141
DOI: 10.1002/gepi.20101

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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