Article
Genome-wide linkage scan reveals three putative breast-cancer-susceptibility loci.
American journal of human genetics - 1 Feb 2009
Rosa-Rosa Juan Manuel, Pita Guillermo, Urioste Miguel, Llort Gemma, Brunet Joan, Lázaro Conxi, Blanco Ignacio, Ramón y Cajal Teresa, Díez Orland, de la Hoya Miguel, Caldés Trinidad, Tejada Maria-Isabel, González-Neira Anna, Benítez Javier
Abstract excerpt
Despite all the research efforts made during the last few decades, most of the cases of families with breast cancer remain unexplained. Mutations in BRCA1 and BRCA2, and in other breast-cancer-susceptibility genes, account for about 25% of familial breast cancer. Linkage studies have failed to identify other breast-cancer-susceptibility genes. The selection criteria of the families, differences in the population...
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