Article
Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.
PloS one - 2 Apr 2010
Rosa-Rosa Juan Manuel, Gracia-Aznárez Francisco Javier, Hodges Emily, Pita Guillermo, Rooks Michelle, Xuan Zhenyu, Bhattacharjee Arindam, Brizuela Leonardo, Silva José M, Hannon Gregory J, Benitez Javier
Abstract excerpt
BACKGROUND: The classical candidate-gene approach has failed to identify novel breast cancer susceptibility genes. Nowadays, massive parallel sequencing technology allows the development of studies unaffordable a few years ago. However, analysis protocols are not yet sufficiently developed to extract all information from the huge amount of data obtained. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we performed...
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