Article
Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families.
Breast cancer research : BCR - 1 Jan 2010
Arason Adalgeir, Gunnarsson Haukur, Johannesdottir Gudrun, Jonasson Kristjan, Bendahl Pär-Ola, Gillanders Elizabeth M, Agnarsson Bjarni A, Jönsson Göran, Pylkäs Katri, Mustonen Aki, Heikkinen Tuomas, Aittomäki Kristiina, Blomqvist Carl, Melin Beatrice, Johannsson Oskar T H, Møller Pål, Winqvist Robert, Nevanlinna Heli, Borg Ake, Barkardottir Rosa B
Abstract excerpt
INTRODUCTION: A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not revealed any single major locus reminiscent of BRCA1 and BRCA2, indicating that still unidentified genes may explain relatively few families each or interact in a way obscure to linkage analyses. This has drawn attention to possible benefits of...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 6
- Family Health