An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in eastern Finland: three candidate regions found.

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An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in eastern Finland: three candidate regions found.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2005

Hartikainen Jaana M, Tuhkanen Hanna, Kataja Vesa, Dunning Alison M, Antoniou Antonis, Smith Paula, Arffman Airi, Pirskanen Mia, Easton Douglas F, Eskelinen Matti, Uusitupa Matti, Kosma Veli-Matti, Mannermaa Arto

Abstract excerpt

Breast cancer is the most common of cancers among women in industrialized countries. Many of breast cancer risk factors are known, but the majority of the genetic background is still unknown. Linkage disequilibrium-based association is a powerful tool for mapping disease genes and is suitable for mapping complex traits in founder populations. We report the results of a two-stage, autosome-wide scan for LD with...

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PMID: 15668479

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