Identification of genes associated with tumor suppression in Syrian hamster embryo cells.

doi:10.1289/ehp.9193105

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Article

Identification of genes associated with tumor suppression in Syrian hamster embryo cells.

Environmental health perspectives - 1 Jun 1991

Wiseman R W, Montgomery J C, Hosoi J, Hou E W, Cochran C J, Lamb P W, Barrett J C

Abstract excerpt

Loss of a tumor-suppressor gene function appears to play a critical role in the multistep process of neoplastic transformation of Syrian hamster embryo (SHE) cells in vitro. Clonal variants of two independent, preneoplastic cell lines have been isolated that have either retained (termed supB+) or lost (termed supB-) the ability to suppress the tumorigenicity of a highly malignant benzo[alpha]pyrene-transformed...

Topics

Animals
Base Sequence
Benzo(a)pyrene
Biomarkers, Tumor
Cell Line, Transformed
Cell Transformation, Neoplastic
Collagen
Cricetinae
DNA
DNA, Neoplasm
Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Genes, Tumor Suppressor

Hybrid Cells

Mesocricetus

Molecular Sequence Data

Phenotype

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1773782
DOI: 10.1289/ehp.9193105
PMCID: PMC1568055

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1773782-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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