Article
The linoleic acid metabolite, (13S)-hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes.
The Journal of biological chemistry - 1 Aug 1997
Glasgow W C, Hui R, Everhart A L, Jayawickreme S P, Angerman-Stewart J, Han B B, Eling T E
Abstract excerpt
In Syrian hamster embryo (SHE) fibroblasts, epidermal growth factor receptor (EGFR) tyrosine kinase activity regulates the metabolism of endogenous linoleic acid to (13S)-hydroperoxyoctadecadienoic acid (13S)-HPODE). (13S)-HPODE stimulates EGF-dependent mitogenesis in a SHE cell phenotype, which expresses tumor suppressor genes (supB+), but was not effective in a variant that does not express these suppressor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.