Article
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation.
Proceedings of the National Academy of Sciences of the United States of America - 23 Nov 1999
Cmarik J L, Min H, Hegamyer G, Zhan S, Kulesz-Martin M, Yoshinaga H, Matsuhashi S, Colburn N H
Abstract excerpt
An mRNA differential display comparison of mouse JB6 promotion-sensitive (P+) and -resistant (P-) cells identified a novel gene product that inhibits neoplastic transformation. The JB6 P+ and P- cells are genetic variants that differ in their transformation response to tumor promoters; P+ cells form anchorage-independent colonies that are tumorigenic, and P- cells do not. A differentially displayed fragment,...
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