Article
Induction of neoplastic progression in Syrian hamster embryo cells treated with protein phosphatase inhibitors.
Cancer research - 15 Apr 1993
Afshari C A, Kodama S, Bivins H M, Willard T B, Fujiki H, Barrett J C
Abstract excerpt
In these studies, Syrian hamster embryo cells (SHE), which were isolated at different stages of neoplastic progression, were used to test the ability of the protein phosphatase inhibitors, okadaic acid and sodium orthovanadate (Na3VO4) to induce neoplastic progression. We observed that these chem...
Topics
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cricetinae
- Dose-Response Relationship, Drug
- Embryo, Mammalian
- Ethers, Cyclic
- Karyotyping
- Mutation
- Okadaic Acid
- Phenotype
- Phosphoprotein Phosphatases
- Vanadates