Article
Preneoplastic alterations in nuclear morphology that accompany loss of tumor suppressor phenotype.
Journal of the National Cancer Institute - 19 Jun 1991
Boyd J, Pienta K J, Getzenberg R H, Coffey D S, Barrett J C
Abstract excerpt
Alterations of nuclear shape are frequently observed in tumor cells, but the genes controlling these changes and the stage in the neoplastic process at which they occur are unknown. We have studied nuclear shape changes in chemically immortalized, nontumorigenic Syrian hamster embryo cell clones...
Topics
- Animals
- Cell Nucleus
- Cells, Cultured
- Cricetinae
- Genes, Suppressor
- Mesocricetus
- Microscopy, Electron
- Neoplasms, Experimental
- Phenotype
- Tumor Cells, Cultured