Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.

doi:10.1128/MCB.21.20.6895-6905.2001

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Article

Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.

Molecular and cellular biology - 1 Oct 2001

Kameda H, Risinger J I, Han B B, Baek S J, Barrett J C, Abe T, Takeuchi T, Glasgow W C, Eling T E

Abstract excerpt

An in vitro transformation system of carcinogen-treated Syrian hamster embryo (SHE) cell cultures represents multistep genetic and nongenetic changes that develop during the neoplastic progression of normal cells to tumor cells in vivo. During this neoplastic progression, SHE cells demonstrate an altered response to epidermal growth factor (EGF). In the present report, we examined the role of the adapter protein...

Topics

Agar
Amino Acid Sequence
Animals
Asbestos
Base Sequence
Blood Proteins
Blotting, Northern
Blotting, Western
Carcinogens
Cell Division
Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cells, Cultured

Cloning, Molecular

Cricetinae

DNA, Complementary

Disease Progression

Epidermal Growth Factor

Fluorescent Antibody Technique, Indirect

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Identifiers

PMID: 11564873
DOI: 10.1128/MCB.21.20.6895-6905.2001
PMCID: PMC99866

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Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.PMID 11564873Read ↗

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.Semantic proximity Read ↗

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Semantic proximity Read ↗

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Semantic proximity Read ↗

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Semantic proximity Read ↗

RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells.Semantic proximity Read ↗

Targeted knockout of BRG1 potentiates lung cancer development.Semantic proximity Read ↗

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Semantic proximity Read ↗

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair.Semantic proximity Read ↗

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.Semantic proximity Read ↗

A role for the scaffolding adapter GAB2 in breast cancer.Semantic proximity Read ↗

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read ↗

Gab1 signaling is regulated by EGF receptor sorting in early endosomes.Semantic proximity Read ↗

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