Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PHF10 Is Required for Cell Proliferation in Normal and SV40-Immortalized Human Fibroblast Cells

1 Jan 2009

Abstract excerpt

Normal human diploid fibroblasts have limited life span in culture and undergo replicative senescence after 50-60 population doublings. On the contrary, cancer cells typically divide indefinitely and are immortal. Expression of SV40 large T and small t antigens in human fibroblasts transiently extends their life span by 20-30 population doublings and facilitates immortalization. We have identified a rearrangement...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genomics and Chromatin Dynamics

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 20068294
DOI: 10.1159/000251960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PHF10 Is Required for Cell Proliferation in Normal and SV40-Immortalized Human Fibroblast CellsPMID 20068294Read ↗

In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40 large T antigen mutants.Semantic proximity Read ↗

Establishment of human fibroma cell lines from a MEN1 patient by introduction of either hTERT or SV40 early region.Semantic proximity Read ↗

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell TransformationSemantic proximity Read ↗

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.Semantic proximity Read ↗

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemiaSemantic proximity Read ↗

Involvement of the specific nucleolar protein SURF6 in regulation of proliferation and ribosome biogenesis in mouse NIH/3T3 fibroblasts.Semantic proximity Read ↗

Multistage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70.Semantic proximity Read ↗

Intestinal Hyperplasia Induced by Simian Virus 40 Large Tumor Antigen Requires E2F2Semantic proximity Read ↗

Simian Virus 40 T-Antigen-Mediated Gene Regulation in Enterocytes Is Controlled Primarily by the Rb-E2F PathwaySemantic proximity Read ↗

The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53Semantic proximity Read ↗

Senescence delay and repression of p16 INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblastsSemantic proximity Read ↗

Human chromosome 21 determines growth factor dependence in human/mouse B-cell hybridomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.