Article
Detection of multiple tumor suppressor genes for Syrian hamster fibrosarcomas by somatic cell hybridization.
Somatic cell and molecular genetics - 1 Mar 1992
Whitehead R E, Sugawara O, Maronpot R R, Gladen B C, Barrett J C
Abstract excerpt
Identification of tumor suppressor gene loci in rodent cell culture systems has relied upon the use of somatic cell hybridization studies. Although normal rodent fibroblasts are capable of suppressing the tumorigenicity of a variety of tumor cells, the lack of complementation in tumor cell x tumo...
Topics
- Animals
- Benzo(a)pyrene
- Cell Transformation, Neoplastic
- Cricetinae
- Embryo, Mammalian
- Fibrosarcoma
- Genes, Tumor Suppressor
- Genes, p53
- Genes, ras
- Genes, src
- Genetic Complementation Test
- Hybrid Cells
- Mesocricetus
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Tumor Stem Cell Assay