Article
Sequential loss of suppressor genes for three specific functions during in vivo carcinogenesis.
Laboratory investigation; a journal of technical methods and pathology - 1 Sept 1990
Moroco J R, Solt D B, Polverini P J
Abstract excerpt
As normal cells undergo neoplastic transformation, multiple suppressor gene functions are lost or inactivated. However, the relative contribution that individual suppressor gene defects play in the sequential evolution of solid tumors has not yet been evaluated in a readily analyzable experimental model of carcinogenesis. The present study was undertaken to: (a) document the loss of suppressor genes implicated in...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cornea
- Cricetinae
- Female
- Hybridomas
- Keratinocytes
- Male
- Neovascularization, Pathologic