Article
Coordinate regulation of collagen II(alpha 1) and H19 expression in immortalized hamster cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1993
Owen R D, Hosoi J, Montgomery J C, Wiseman R, Barrett J C
Abstract excerpt
Loss of tumor suppressor gene function is essential in the multistep progression of cells to neoplasia. Immortalized cells were established by carcinogen treatment of Syrian hamster embryo cells. At early passages, these nontumorigenic cells retained the ability to suppress tumorigenicity in cell hybrids with malignant cells. Upon passage and subcloning of these suppressor-positive (supB+) cells, variant clones...
Topics
- Animals
- Base Sequence
- Cell Line, Transformed
- Cells, Cultured
- Collagen
- Cricetinae
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Molecular Sequence Data
- Phenotype