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Article

Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape.

Journal of virology - 1 Nov 2007

Liu Yi, McNevin John, Zhao Hong, Tebit Denis M, Troyer Ryan M, McSweyn Matthew, Ghosh Ananta K, Shriner Daniel, Arts Eric J, McElrath M Juliana, Mullins James I

Abstract excerpt

CD8(+) cytotoxic T lymphocytes (CTL) are strong mediators of human immunodeficiency virus type 1 (HIV-1) control, yet HIV-1 frequently mutates to escape CTL recognition. In an analysis of sequences in the Los Alamos HIV-1 database, we show that emerging CTL escape mutations were more often present at lower frequencies than the amino acid(s) that they replaced. Furthermore, epitopes that underwent escape contained...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

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Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 17728222
DOI: 10.1128/JVI.01277-07
PMCID: PMC2169017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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