Article
Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual.
Journal of virology - 1 Dec 2003
Geels Mark J, Cornelissen Marion, Schuitemaker Hanneke, Anderson Kiersten, Kwa David, Maas Jolanda, Dekker John T, Baan Elly, Zorgdrager Fokla, van den Burg Remco, van Beelen Martijn, Lukashov Vladimir V, Fu Tong-Ming, Paxton William A, van der Hoek Lia, Dubey Sheri A, Shiver John W, Goudsmit Jaap
Abstract excerpt
Control of viremia in natural human immunodeficiency virus type 1 (HIV-1) infection in humans is associated with a virus-specific T-cell response. However, still much is unknown with regard to the extent of CD8(+) cytotoxic T-lymphocyte (CTL) responses required to successfully control HIV-1 infection and to what extent CTL epitope escape can account for rises in viral load and ultimate progression to disease. In...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA Primers
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Genes, Viral
- HIV Infections
- HIV-1