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Article

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.

PLoS pathogens - 1 Apr 2009

Troyer Ryan M, McNevin John, Liu Yi, Zhang Shao Chong, Krizan Randall W, Abraha Awet, Tebit Denis M, Zhao Hong, Avila Santiago, Lobritz Michael A, McElrath M Juliana, Le Gall Sylvie, Mullins James I, Arts Eric J

Abstract excerpt

Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escape mutations emerging in seven CTL epitopes in the gp120 Env and p24 Gag coding regions of an individual followed...

Read the complete abstract on PubMed

Topics

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Share to Epitopes, T-Lymphocyte
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to Human Immunodeficiency Virus Proteins

Share to Peptide Fragments

Share to T-Lymphocytes, Cytotoxic

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 19343217
DOI: 10.1371/journal.ppat.1000365
PMCID: PMC2659432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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