Article
Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.
Nature immunology - 1 Feb 2006
Iversen Astrid K N, Stewart-Jones Guillaume, Learn Gerald H, Christie Natasha, Sylvester-Hviid Christina, Armitage Andrew E, Kaul Rupert, Beattie Tara, Lee Jean K, Li Yanping, Chotiyarnwong Pojchong, Dong Tao, Xu Xiaoning, Luscher Mark A, MacDonald Kelly, Ullum Henrik, Klarlund-Pedersen Bente, Skinhøj Peter, Fugger Lars, Buus Søren, Mullins James I, Jones E Yvonne, van der Merwe P Anton, McMichael Andrew J
Abstract excerpt
Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found two principal, diametrically opposed evolutionary pathways that exclusively affect T cell-receptor contact residues....
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