Article
Reversion of CTL escape-variant immunodeficiency viruses in vivo.
Nature medicine - 1 Mar 2004
Friedrich Thomas C, Dodds Elizabeth J, Yant Levi J, Vojnov Lara, Rudersdorf Richard, Cullen Candice, Evans David T, Desrosiers Ronald C, Mothé Bianca R, Sidney John, Sette Alessandro, Kunstman Kevin, Wolinsky Steven, Piatak Michael, Lifson Jeffrey, Hughes Austin L, Wilson Nancy, O'Connor David H, Watkins David I
Abstract excerpt
Engendering cytotoxic T-lymphocyte (CTL) responses is likely to be an important goal of HIV vaccines. However, CTLs select for viral variants that escape immune detection. Maintenance of such escape variants in human populations could pose an obstacle to HIV vaccine development. We first observed that escape mutations in a heterogeneous simian immunodeficiency virus (SIV) isolate were lost upon passage to new...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.