Article
De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.
Journal of virology - 1 Oct 2005
Allen Todd M, Yu Xu G, Kalife Elizabeth T, Reyor Laura L, Lichterfeld Mathias, John Mina, Cheng Michael, Allgaier Rachel L, Mui Stanley, Frahm Nicole, Alter Galit, Brown Nancy V, Johnston Mary N, Rosenberg Eric S, Mallal Simon A, Brander Christian, Walker Bruce D, Altfeld Marcus
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) evades CD8(+) T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8(+) T-cell responses to such mutants. Here we examined gamma interferon-positive, HIV-1-specific CD8(+) T-cell responses and autologous viral sequences in an HIV-1-infected individual for more than 6 years following acute infection....
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