Article
Dynamics of viral evolution and CTL responses in HIV-1 infection.
PloS one - 20 Jan 2011
Liu Yi, McNevin John P, Holte Sarah, McElrath M Juliana, Mullins James I
Abstract excerpt
Improved understanding of the dynamics of host immune responses and viral evolution is critical for effective HIV-1 vaccine design. We comprehensively analyzed Cytotoxic T-lymphocyte (CTL)-viral epitope dynamics in an antiretroviral therapy-naïve subject over the first four years of HIV-1 infection. We found that CTL responses developed sequentially and required constant antigenic stimulation for maintenance. CTL...
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