Article
Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts.
Journal of virology - 1 Sept 2004
Friedrich Thomas C, McDermott Adrian B, Reynolds Matthew R, Piaskowski Shari, Fuenger Sarah, De Souza Ivna P, Rudersdorf Richard, Cullen Candice, Yant Levi J, Vojnov Lara, Stephany Jason, Martin Sarah, O'Connor David H, Wilson Nancy, Watkins David I
Abstract excerpt
Cytotoxic T lymphocytes (CTL) are associated with control of immunodeficiency virus infection but also select for variants that escape immune recognition. Declining frequencies of epitope-specific CTL frequencies have been correlated with viral escape in individual hosts. However, escape mutations may give rise to new epitopes that could be recognized by CTL expressing appropriate T-cell receptors and thus still...
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