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Article

Epitope escape mutation and decay of human immunodeficiency virus type 1-specific CTL responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2003

Jamieson Beth D, Yang Otto O, Hultin Lance, Hausner Mary Ann, Hultin Patricia, Matud Jose, Kunstman Kevin, Killian Scott, Altman John, Kommander Kristina, Korber Bette, Giorgi Janis, Wolinsky Steven

Abstract excerpt

To investigate possible mechanisms behind HIV-1 escape from CTL, we performed detailed longitudinal analysis of Gag (SLYNTVATL)- and RT (ILKEPVHGV)-specific CTL responses and plasma epitope sequences in five individuals. Among those with CTL against consensus epitope sequences, epitope mutations developed over several years, invariably followed by decay of the CTL targeting the consensus epitopes. The maturation...

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Share to CD8-Positive T-Lymphocytes
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Gene Products, gag

Share to Gene Products, pol

Share to HIV Seropositivity

Share to Lymphocyte Count

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 14607940
DOI: 10.4049/jimmunol.171.10.5372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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