Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of human Hsp27 inhibits serum-induced proliferation in airway smooth muscle myocytes and confers resistance to hydrogen peroxide cytotoxicity.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2007

Salinthone Sonemany, Ba Mariam, Hanson Lisa, Martin Jody L, Halayko Andrew J, Gerthoffer William T

Abstract excerpt

Airway smooth muscle (ASM) hypertrophy and hyperplasia are characteristics of asthma that lead to thickening of the airway wall and obstruction of airflow. Very little is known about mechanisms underlying ASM remodeling, but in vascular smooth muscle, it is known that progression of atherosclerosis depends on the balance of myocyte proliferation and cell death. Small heat shock protein 27 (Hsp27) is antiapoptotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP27 Heat-Shock Proteins

Share to Necrosis

Share to Oxidants

Share to p38 Mitogen-Activated Protein Kinases

Share to Respiratory System

Source

Identifiers

PMID: 17720870
DOI: 10.1152/ajplung.00453.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of human Hsp27 inhibits serum-induced proliferation in airway smooth muscle myocytes and confers resistance to hydrogen peroxide cytotoxicity.PMID 17720870Read ↗

Effect of phosphorylated hsp27 on proliferation of human endothelial and smooth muscle cells.Semantic proximity Read ↗

Research progress on the mechanism of phenotypic transformation of pulmonary artery smooth muscle cells induced by hypoxiaSemantic proximity Read ↗

Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages.Semantic proximity Read ↗

Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.Semantic proximity Read ↗

Direct Effects of Cigarette Smoke in Pulmonary Arterial Cells alter Vascular Tone through Arterial Remodeling and Kv7.4 Channel DysregulationSemantic proximity Read ↗

Inhibition of Daxx-mediated apoptosis by heat shock protein 27.Semantic proximity Read ↗

Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model.Semantic proximity Read ↗

β-sitosterol alleviates pulmonary arterial hypertension by altering smooth muscle cell phenotype and DNA damage/cGAS/STING signaling.Semantic proximity Read ↗

Nicotinamide phosphoribosyltransferase activates the mitochondrial unfolded protein response to promote pulmonary arterial endothelial cell proliferationSemantic proximity Read ↗

Serine mutations in overexpressed Hsp27 abrogate the protection against doxorubicin-induced p53-dependent cardiac apoptosis in mice.Semantic proximity Read ↗

Mechanosensitive Stanniocalcin-1 Attenuates Pulmonary Arterial Hypertension by Suppressing Smooth Muscle Cell ProliferationSemantic proximity Read ↗

Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress-response pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.