Article

Nicotinamide phosphoribosyltransferase activates the mitochondrial unfolded protein response to promote pulmonary arterial endothelial cell proliferation

2026-01-16

Abstract excerpt

Vascular remodeling leading to occlusion of the pulmonary artery and increased pulmonary vascular resistance is the central feature of Pulmonary Arterial Hypertension (PAH) which leads to death due to right heart failure. The expression of Nicotinamide phosphoribosyltransferase (Nampt) is increased in the lungs and isolated PAECs of PAH patients. Inhibition of NAMPT is protective in preclinical models of pulmonary...

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Literature Corpus work: 86e86881-eca2-5825-9c01-f6c0c68ceb70
DOI: 10.64898/2026.01.15.699710

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