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Article

Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress-response pathway.

The Journal of biological chemistry - 11 Aug 2017

Yadav Vinita, Gao Xing-Huang, Willard Belinda, Hatzoglou Maria, Banerjee Ruma, Kabil Omer

Abstract excerpt

Hydrogen sulfide (H2S) regulates various physiological processes, including neuronal activity, vascular tone, inflammation, and energy metabolism. Moreover, H2S elicits cytoprotective effects against stressors in various cellular models of injury. However, the mechanism of the signaling pathways mediating the cytoprotective functions of H2S is not well understood. We previously uncovered a heme-dependent...

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Identifiers

PMID: 28637872
DOI: 10.1074/jbc.M117.778654
PMCID: PMC5555178

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