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Research progress on the mechanism of phenotypic transformation of pulmonary artery smooth muscle cells induced by hypoxia

1 Dec 2022

Abstract excerpt

Phenotypic transformation of pulmonary artery smooth muscle cells (PASMCs) is a key factor in pulmonary vascular remodeling. Inhibiting or reversing phenotypic transformation can inhibit pulmonary vascular remodeling and control the progression of hypoxic pulmonary hypertension. Recent studies have shown that hypoxia causes intracellular peroxide metabolism to induce oxidative stress, induces multi-pathway signal...

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PMID: 36915980
DOI: 10.3724/zdxbyxb-2022-0282

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