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Article

Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.

American journal of respiratory and critical care medicine - 15 Mar 2004

Zhou Limei, Li Jing, Goldsmith Adam M, Newcomb Dawn C, Giannola Diane M, Vosk Robert G, Eves Eva M, Rosner Marsha R, Solway Julian, Hershenson Marc B

Abstract excerpt

We developed clonal cell lines of human bronchial smooth muscle origin by retroviral transduction of temperature-sensitive simian virus 40 large tumor (T) antigen. These cells show increased growth potential at 33 degrees C, but on shift to the nonpermissive temperature (39 degrees C), they show diminished or arrested growth. In addition to the expected reduction in the level of large T antigen, cells shifted to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14693670
DOI: 10.1164/rccm.200307-964OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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