Article

Mechanosensitive Stanniocalcin-1 Attenuates Pulmonary Arterial Hypertension by Suppressing Smooth Muscle Cell Proliferation

2025-10-15

Abstract excerpt

<h4>Background</h4> Idiopathic pulmonary arterial hypertension (IPAH) is driven by progressive pulmonary vascular remodeling, particularly pulmonary arterial smooth muscle cell (PASMC) proliferation. Current combination vasodilator therapies have markedly improved outcomes; however, prognosis remains poor in subgroups such as patients with respiratory comorbidities, highlighting the need for novel therapies. Elev...

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Literature Corpus work: 01007d4c-4472-541e-b523-2f9961ddcba2
DOI: 10.1101/2025.10.13.682225

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