Article
Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages.
Cell stress & chaperones - 1 Jan 2013
Salari Samira, Seibert Tara, Chen Yong-Xiang, Hu Tieqiang, Shi Chunhua, Zhao Xiaoling, Cuerrier Charles M, Raizman Joshua E, O'Brien Edward R
Abstract excerpt
Heat shock protein 27 (HSP27) shows attenuated expression in human coronary arteries as the extent of atherosclerosis progresses. In mice, overexpression of HSP27 reduces atherogenesis, yet the precise mechanism(s) are incompletely understood. Inflammation plays a central role in atherogenesis, and of particular interest is the balance of pro- and anti-inflammatory factors produced by macrophages. As nuclear...
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