Article
Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model.
Circulation - 7 Dec 2004
Hollander John M, Martin Jody L, Belke Darrell D, Scott Brian T, Swanson Eric, Krishnamoorthy Vignesh, Dillmann Wolfgang H
Abstract excerpt
BACKGROUND: The small heat shock protein 27 (hsp27) increases in expression with ischemia/reperfusion (I/R) insult in the heart. One feature of the small hsps is their ability to oligomerize and form intracellular aggregates. Oligomerization pattern is governed by the phosphorylation state of the protein that may influence their ability to protect against cellular stresses. METHODS AND RESULTS: We generated...
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