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Article

Serine mutations in overexpressed Hsp27 abrogate the protection against doxorubicin-induced p53-dependent cardiac apoptosis in mice.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2021

Kanagasabai Ragu, Karthikeyan Krishnamurthy, Zweier Jay L, Ilangovan Govindasamy

Abstract excerpt

Small heat shock proteins (sHsps) protect the heart from chemotherapeutics-induced heart failure by inhibiting p53-dependent apoptosis. However, mechanism of such protection has not been elucidated yet. Here we test a hypothesis that serine phosphorylation of sHsps is essential to inhibit the doxorubicin-induced and p53-dependent apoptotic pathway. Three transgenic mice (TG) lines with cardiomyocyte-specific...

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PMID: 34477462
DOI: 10.1152/ajpheart.00027.2020

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