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Article

β-sitosterol alleviates pulmonary arterial hypertension by altering smooth muscle cell phenotype and DNA damage/cGAS/STING signaling.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Dec 2024

Li Jing, Meng Zhong-Yuan, Wen Hong, Lu Chuang-Hong, Qin Yue, Xie Yi-Ming, Chen Qi, Lv Jin-Hui, Huang Feng, Zeng Zhi-Yu

Abstract excerpt

BACKGROUND: Pulmonary arterial smooth muscle cells (PASMCs) have a neoplastic phenotype characterized by hyperproliferative and anti-apoptotic features that contribute to pulmonary hypertension (PH) development. DNA-sensing adapter protein stimulator of interferon genes (STING) regulate the phenotypic switch of vessel smooth muscle cells. β-sitosterol (SITO) is a nutrient derived from plants that inhibits...

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PMID: 39265206
DOI: 10.1016/j.phymed.2024.156030

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