Article
Low-activity allele of Catechol-O-Methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosis.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Oct 2007
Crespo-Facorro Benedicto, Roiz-Santiáñez Roberto, Pelayo-Terán José María, Pérez-Iglesias Rocío, Carrasco-Marín Eugenio, Mata Ignacio, González-Mandly Andrés, Jorge Ricardo, Vázquez-Barquero José Luis
Abstract excerpt
BACKGROUND: Structural brain anomalies are present at early phases of psychosis. The objective was to examine the impact of Catechol-O-Methyltransferase (COMT) gene variations on brain morphology in first-episode non-affective psychosis. We hypothesized that the low activity-COMT (COMT(L)) allele would be associated with the presence of structural brain changes as assessed by quantitative magnetic resonance...
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