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Article

Catechol-O-methyltransferase genotype and dopamine regulation in the human brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 2003

Akil Mayada, Kolachana Bhaskar S, Rothmond Debora A, Hyde Thomas M, Weinberger Daniel R, Kleinman Joel E

Abstract excerpt

A functional polymorphism in the gene for catechol-O-methyltransferase (COMT) has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans, probably by affecting prefrontal dopamine signaling. The COMT valine allele, associated with relatively poor prefrontal...

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Identifiers

PMID: 12657658
PMCID: PMC6742018

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12657658-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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