Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.

Nature neuroscience - 1 Nov 2005

Gothelf Doron, Eliez Stephan, Thompson Tracy, Hinard Christine, Penniman Lauren, Feinstein Carl, Kwon Hower, Jin Shuting, Jo Booil, Antonarakis Stylianos E, Morris Michael A, Reiss Allan L

Abstract excerpt

Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMT(L)) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 22

Share to Cognition Disorders

Share to DiGeorge Syndrome

Share to Longitudinal Studies

Share to Neuropsychological Tests

Share to Psychiatric Status Rating Scales

Source

Identifiers

PMID: 16234808
DOI: 10.1038/nn1572

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.PMID 16234808Read ↗

Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Neuroimaging correlates of 22q11.2 deletion syndrome: implications for schizophrenia research.Semantic proximity Read ↗

Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Risk Factors for the Emergence of Psychotic Disorders in Adolescents With 22q11.2 Deletion SyndromeSemantic proximity Read ↗

Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.Semantic proximity Read ↗

Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility.Semantic proximity Read ↗

Dopamine metabolism in adults with 22q11 deletion syndrome, with and without schizophrenia--relationship with COMT Val¹⁰⁸/¹⁵⁸Met polymorphism, gender and symptomatology.Semantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.