Article
Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives.
Schizophrenia research - 1 Sept 2020
Hochberger William C, Eskridge Courtney L M, Bishop Jeffrey R, Reilly James L, Rubin Leah H, Keedy Sarah, Gershon Elliot S, Tamminga Carol A, Pearlson Godfrey D, Ragozzino Michael, Keshavan Matcheri S, Sweeney John A, Hill S Kristian
Abstract excerpt
Dopaminergic activity in prefrontal cortex is modulated by the low (Met) and high (Val) activity of the rs4680 Val158Met single nucleotide polymorphism (SNP) in the Catechol-O-Methyltransferase (COMT) gene. While this has been related to working memory maintenance in patients with schizophrenia, the familial pattern, impact across the psychosis spectrum, and the role of this genotype on other aspects of behavior,...
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