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Article

Met158 variant of the catechol-O-methyltransferase genotype is associated with thicker cortex in adult brain.

Neuroscience - 19 May 2010

Cerasa A, Cherubini A, Quattrone A, Gioia M C, Tarantino P, Annesi G, Assogna F, Caltagirone C, Spalletta G

Abstract excerpt

Cortical thickness has been proposed as a new promising brain imaging endophenotype in elucidating the nature of gene-brain relationships. Here, we define the morphological impact of the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene on human brain anatomy. One hundred and forty-nine adult healthy subjects (mean age: 40.7+/-16.1; ranging from 19 to 76 years) were genotyped (38 in the...

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Identifiers

PMID: 20219642
DOI: 10.1016/j.neuroscience.2010.02.040

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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