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Article

Association analysis of the COMT/MTHFR genes and geriatric depression: an MRI study of the putamen.

International journal of geriatric psychiatry - 1 Aug 2009

Pan Chih-Chuan, McQuoid Douglas R, Taylor Warren D, Payne Martha E, Ashley-Koch Allison, Steffens David C

Abstract excerpt

OBJECTIVE: Catechol-O-Methyltransferase (COMT) and Methylenetetrahydrofolate reductase (MTHFR) had been reported to relate to depression but with inconsistent results. The basal ganglia are also important in the pathophysiology of affective disorder via connections with limbic system and prefrontal cortex. The authors examined the relationship between an interaction of COMT/MTHFR polymorphisms and volumes of...

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Source

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Identifiers

PMID: 19235787
DOI: 10.1002/gps.2206
PMCID: PMC2711996

Genes

COMT
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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