Article
The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults.
NeuroImage - 15 Nov 2010
Ehrlich Stefan, Morrow Eric M, Roffman Joshua L, Wallace Stuart R, Naylor Melissa, Bockholt H Jeremy, Lundquist Antonia, Yendiki Anastasia, Ho Beng-Choon, White Tonya, Manoach Dara S, Clark Vincent P, Calhoun Vince D, Gollub Randy L, Holt Daphne J
Abstract excerpt
Abnormalities of the medial temporal lobe have been consistently demonstrated in schizophrenia. A common functional polymorphism, Val108/158Met, in the putative schizophrenia susceptibility gene, catechol-O-methyltransferase (COMT), has been shown to influence medial temporal lobe function. However, the effects of this polymorphism on volumes of medial temporal lobe structures, particularly in patients with...
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