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Article

Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users.

Addiction biology - 1 Jul 2014

Batalla Albert, Soriano-Mas Carles, López-Solà Marina, Torrens Marta, Crippa José A, Bhattacharyya Sagnik, Blanco-Hinojo Laura, Fagundo Ana B, Harrison Ben J, Nogué Santiago, de la Torre Rafael, Farré Magí, Pujol Jesús, Martín-Santos Rocío

Abstract excerpt

Neuroimaging studies have shown that chronic consumption of cannabis may result in alterations in brain morphology. Recent work focusing on the relationship between brain structure and the catechol-O-methyltransferase (COMT) gene polymorphism suggests that functional COMT variants may affect brain volume in healthy individuals and in schizophrenia patients. We measured the influence of COMT genotype on the volume...

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Identifiers

PMID: 23311613
DOI: 10.1111/adb.12027

Genes

COMT

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Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users.PMID 23311613Read ↗

The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.Semantic proximity Read ↗

Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging.Semantic proximity Read ↗

Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-naïve patients with schizophrenia.Semantic proximity Read ↗

Met158 variant of the catechol-O-methyltransferase genotype is associated with thicker cortex in adult brain.Semantic proximity Read ↗

The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults.Semantic proximity Read ↗

Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism.Semantic proximity Read ↗

Impact of catechol-O-methyltransferase Val(108/158) Met genotype on hippocampal and prefrontal gray matter volume.Semantic proximity Read ↗

Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis.Semantic proximity Read ↗

The importance of identifying functional Val158Met polymorphism in catechol-O- Methyltransferase when assessing MRI-based volumetric measurements in major depressive disorder.Semantic proximity Read ↗

Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndromeSemantic proximity Read ↗

Impact of interacting functional variants in COMT on regional gray matter volume in human brain.Semantic proximity Read ↗

The COMT val158met polymorphism and brain morphometry in healthy young adults.Semantic proximity Read ↗

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