Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational regulation of human methionine synthase by upstream open reading frames.

Biochimica et biophysica acta - 1 Jan 2000

Col Bekir, Oltean Sebastian, Banerjee Ruma

Abstract excerpt

Methionine synthase is a key enzyme poised at the intersection of folate and sulfur metabolism and functions to reclaim homocysteine to the methionine cycle. The 5' leader sequence in human MS is 394 nucleotides long and harbors two open reading frames (uORFs). In this study, regulation of the main open reading frame by the uORFs has been elucidated. Both uORFs downregulate translation as demonstrated by mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Codon, Initiator

Share to Down-Regulation

Share to Mutation

Share to Open Reading Frames

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 17683808
DOI: 10.1016/j.bbaexp.2007.06.003
PMCID: PMC2682437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational regulation of human methionine synthase by upstream open reading frames.PMID 17683808Read ↗

Gene expression regulation by upstream open reading frames and human disease.Semantic proximity Read ↗

Some like it translated: small ORFs in the 5′UTRSemantic proximity Read ↗

Translation of numerous upstream open reading frames rather than their products is essential for proliferation of human cells of distinct originSemantic proximity Read ↗

uORFdb--a comprehensive literature database on eukaryotic uORF biology.Semantic proximity Read ↗

Role of 5'- and 3'-untranslated regions of mRNAs in human diseases.Semantic proximity Read ↗

Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia.Semantic proximity Read ↗

Sequence-intrinsic barriers define a class of translation-restricted uORFs in the human genomeSemantic proximity Read ↗

Upstream open reading frames: molecular switches in (patho)physiology.Semantic proximity Read ↗

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read ↗

Tight translation regulation of the canonical C9ORF72 through a multi-component systemSemantic proximity Read ↗

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcriptsSemantic proximity Read ↗

Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.