Article

Tight translation regulation of the canonical C9ORF72 through a multi-component system

2025-08-09

Abstract excerpt

C9ORF72 is involved in multiple neuronal functions and a major factor in Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease. Pathogenicity is implemented through an intronic repeat expansion in the gene’s mRNA leader that produces long, repetitive RNA and dipeptides when translated through a non-canonical mechanism. In contrast, despite the presence of ribosome-occupied, regulatory elements in the mR...

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Literature Corpus work: bf8f51ff-0466-5809-84f8-93d978d65abc
DOI: 10.1101/2025.08.09.669471

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