Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts

5 Jan 2018

Abstract excerpt

Abstract Expansion of G4C2 repeats in the C9ORF72 gene is the most prevalent inherited form of amyotrophic lateral sclerosis and frontotemporal dementia. Expanded transcripts undergo repeat-associated non-AUG (RAN) translation producing dipeptide repeat proteins from all reading frames. We determined cis-factors and trans-factors influencing translation of the human C9ORF72 transcripts. G4C2 translation operates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to RNA and protein synthesis mechanisms
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29323119
DOI: 10.1038/s41467-017-02643-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcriptsPMID 29323119Read ↗

Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codonsSemantic proximity Read ↗

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress responseSemantic proximity Read ↗

Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translationSemantic proximity Read ↗

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylationSemantic proximity Read ↗

Reconstitution of <i>C9orf72</i> (GGGGCC) repeat-associated non-AUG translation with purified componentsSemantic proximity Read ↗

RNA regulates repeat-associated non-AUG (RAN) translation initiation in <i>C9orf72</i> FTD/ALSSemantic proximity Read ↗

Repeat-associated non-ATG (RAN) translation.Semantic proximity Read ↗

Tight translation regulation of the canonical C9ORF72 through a multi-component systemSemantic proximity Read ↗

Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes.Semantic proximity Read ↗

Repeat-associated non-ATG (RAN) translation in neurological disease.Semantic proximity Read ↗

eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALSSemantic proximity Read ↗

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.