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Article

Upstream open reading frames: molecular switches in (patho)physiology.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 2010

Wethmar Klaus, Smink Jeske J, Leutz Achim

Abstract excerpt

Conserved upstream open reading frames (uORFs) are found within many eukaryotic transcripts and are known to regulate protein translation. Evidence from genetic and bioinformatic studies implicates disturbed uORF-mediated translational control in the etiology of human diseases. A genetic mouse model has recently provided proof-of-principle support for the physiological relevance of uORF-mediated translational...

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Identifiers

PMID: 20726009
DOI: 10.1002/bies.201000037
PMCID: PMC3045505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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